Current Issue : January-March Volume : 2012 Issue Number : 1 Articles : 2 Articles
Use of herbs in kidney stone is well practiced in traditional medicine. Present study was designed to investigate antiurolithic activity of hydroalcoholic extract of whole herb of Digera muricata on experimental model of urolithiasis. Urolithasis was induced by administration of ethylene glycol (0.75%). It was observed that in selected animal model urolithiasis developed significantly. At 100mg/kg, 200mg/kg and 400mg/kg extract significantly decreased level of stone forming agents, oxalate, calcium and phosphate in kidney as well as urine. Level of BUN, uric acid and creatinine was also found to significantly less as compared to control group. Thus from present study it can be concluded that hydroalcoholic extract of Digera muricata possess significant antiurolithic activity at selected doses....
Hepatomegally is often a complication of sever malaria. The liver is known to be involved in the metabolism of many drugs. Since dihydroartemisinin has been shown to be efficacious in clinical malaria treatment, we examined the effects of dihydroartemisinin on the liver.The study investigated the effects of 5 days and 7days oral dihydroartemisinin (DHA) treatments on the liver of Wistar albino rats. The dosage regimens of oral dihydroartemisinin employed in the study were: a single dosage regimen of 1mg/kg; a repeated dosage regimen of 1mg/kg; 2mg/kg; 60mg/kg and 80mg/kg. Histological observation of tissue micrographs of the DHA-treated and control rats showed that DHA produced an enhancement of the hepatic blood flow through less pronounced dilation of the hepatic arteries and more pronounced dilation of the hepatic portal veins and sinusoid spaces. The hepatic blood vessel dilation effects of DHA in the liver which was absent in controls were dose, repetition and time dependent....
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